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ARP 101

Cat. No. 2622 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of MMP-2
化学名： (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ARP 101

ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).

技术数据 for ARP 101

分子量 406.5
公式 C20H26N2O5S
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 849773-63-3
PubChem ID 11292680
InChI Key DGZZVIWCMGVHGV-LJQANCHMSA-N
Smiles O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)[C@H]([C@@H](C)C)C(NO)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ARP 101

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.65 100
ethanol 10.16 25

制备储备液 for ARP 101

以下数据基于产品分子量 406.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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产品说明书 for ARP 101

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ARP 101

参考文献是支持产品生物活性的出版物。

Tuccinardi et al (2006) Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 14 4260 PMID: 16483784

If you know of a relevant reference for ARP 101, please let us know.

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关键词: ARP 101, ARP 101 supplier, inhibitors, inhibits, MMP-2, Matrix, Metalloprotease, Matrixins, Metalloproteinase, MMP, Proteinases, Proteases, ARP101, 2622, Tocris Bioscience

3 篇 ARP 101 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ARP 101 的部分引用包括：

Rocha-Azevedo et al (2015) PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2. Hum Reprod 26 1098 PMID: 25589674

Li et al (2013) NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Oncotarget 28 2822 PMID: 23856325

Sun et al (2017) Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem 41 2319 PMID: 28463834

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