主页 / 药理学 / Enzymes / ATPases / Kinesin / Kinesin Inhibitors / ARRY 520 trifluoroacetate

ARRY 520 trifluoroacetate

Cat. No. 4676 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
别名： Filanesib
化学名： (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ARRY 520 trifluoroacetate

ARRY 520 trifluoroacetate is a potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.

技术数据 for ARRY 520 trifluoroacetate

分子量 420.48
公式 C20H22F2N4O2S.CF3CO2H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1781834-99-8
PubChem ID 90488964
InChI Key CIJUJPVFECBUKG-BDQAORGHSA-N
Smiles FC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ARRY 520 trifluoroacetate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.54 75
ethanol 31.54 75

制备储备液 for ARRY 520 trifluoroacetate

以下数据基于产品分子量 420.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 3.17 mL 15.85 mL 31.71 mL
3.75 mM 0.63 mL 3.17 mL 6.34 mL
7.5 mM 0.32 mL 1.59 mL 3.17 mL
37.5 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for ARRY 520 trifluoroacetate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for ARRY 520 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Woessner et al (2009) ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 29 4373 PMID: 20032381

Tunquist et al (2010) Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520. Mol.Cancer.Ther. 9 2046 PMID: 20571074

Kim et al (2009) KSP inhibitor ARRY-520 as a substitute for PacT. in type I ovarian cancer cells. J.Transl.Med. 7 63 PMID: 19619321

If you know of a relevant reference for ARRY 520 trifluoroacetate, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Kinesin Inhibitors

关键词: ARRY 520 trifluoroacetate, ARRY 520 trifluoroacetate supplier, ARRY520, trifluoroacetate, potent, selective, kinesin, spindle, protein, KSP, inhibitors, inhibits, antitumor, degrades, Mcl-1, Filanesib, Kinesin, Bcl-2, Family, 4676, Tocris Bioscience

1 篇 ARRY 520 trifluoroacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ARRY 520 trifluoroacetate 的部分引用包括：

Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263

您是否知道使用了 Tocris ARRY 520 trifluoroacetate 的优秀论文？ 请告知我们.

ARRY 520 trifluoroacetate 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used ARRY 520 trifluoroacetate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen.
By Anonymous on 03/26/2020
分析类型： In Vitro
种属： Human
细胞系/组织： T cell line

5uM

PMID: 30970263
review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets