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Artemisinin

Cat. No. 2668 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2668 has been discontinued.

说明： Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
别名： Qinghaosu
化学名： (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for Artemisinin

Artemisinin is an antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (Ki ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

技术数据 for Artemisinin

分子量 282.33
公式 C15H22O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 63968-64-9
PubChem ID 68827
InChI Key BLUAFEHZUWYNDE-NNWCWBAJSA-N
Smiles O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Artemisinin

参考文献是支持产品生物活性的出版物。

Balint (2001) Artemisinin and its derivatives. An important new class of antimalarial agents. Pharmacol.Ther. 90 261 PMID: 11578659

Eckstein-Ludwig et al (2003) Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 957 PMID: 12931192

Wartenberg et al (2003) The antimalarial agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies. Lab.Invest. 83 1647 PMID: 14615418

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关键词: Artemisinin, Artemisinin supplier, Antimalarial, inhibits, inhibitors, P-type, ATPase, PfATP6, P, falciparum, Calcium-ATPase, SERCA, PMCA, Ca2+-ATPase, Ion, Transporters, Pumps, P-Type, V-Type, E-Type, F-Type, ATPases, GTPases, Ca2+, modulators, Signaling, Signalling, Calcium, Qinghaosu, Antimalarials, 2668, Tocris Bioscience

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