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ASP 2535

Cat. No. 5308 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective GlyT1 inhibitor
化学名： 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ASP 2535

ASP 2535 is a potent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.

化合物库 for ASP 2535

ASP 2535 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ASP 2535

分子量 382.42
公式 C22H18N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 374886-51-8
PubChem ID 9800113
InChI Key FQGLDGKVKDPVLO-UHFFFAOYSA-N
Smiles CC(C)C1=NN=C(C4=CN=C(C5=CC=CC=C5)C=C4)N1C3=CC=CC2=NON=C23

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ASP 2535

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 38.24 100
ethanol 38.24 100

制备储备液 for ASP 2535

以下数据基于产品分子量 382.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.07 mL 26.15 mL
5 mM 0.52 mL 2.61 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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参考文献 for ASP 2535

参考文献是支持产品生物活性的出版物。

Harada et al (2012) A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's diseas Eur.J.Pharmacol. 685 59 PMID: 22542656

If you know of a relevant reference for ASP 2535, please let us know.

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关键词: ASP 2535, ASP 2535 supplier, ASP2535, potent, selective, glycine, transporters, GlyT1, inhibitors, inhibits, schizophrenia, alzheimer's, disease, Glycine, Transporters, 5308, Tocris Bioscience

1 篇 ASP 2535 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ASP 2535 的部分引用包括：

Rita U et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74 PMID: 25096780

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