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Submit ReviewAspirin
说明： Cyclooxygenase inhibitor; NSAID
化学名： 2-Acetoxybenzoic acid
纯度： ≥99% (HPLC)
生物活性 for Aspirin
Aspirin is an inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.
化合物库 for Aspirin
Aspirin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Aspirin
| 分子量 | 180.16 |
| 公式 | C9H8O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 50-78-2 |
| PubChem ID | 2244 |
| InChI Key | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
| Smiles | CC(OC1=C(C(O)=O)C=CC=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Aspirin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.8 | 10 | |
| DMSO | 18.02 | 100 |
制备储备液 for Aspirin
以下数据基于产品分子量 180.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.55 mL | 27.75 mL | 55.51 mL |
| 5 mM | 1.11 mL | 5.55 mL | 11.1 mL |
| 10 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 50 mM | 0.11 mL | 0.56 mL | 1.11 mL |
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产品说明书 for Aspirin
参考文献 for Aspirin
参考文献是支持产品生物活性的出版物。
Schror (1997) Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin.Thromb.Hemost. 23 349 PMID: 9263351
Wu et al (1991) Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc.Natl.Acad.Sci.U.S.A. 15 88 PMID: 1900943
Baron (1995) Aspirin and cancer. Preventative Medicine 24 121 PMID: 7597012
If you know of a relevant reference for Aspirin, please let us know.
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关键词: Aspirin, Aspirin supplier, cyclooxygenase, inhibitors, inhibits, antithrombotic, antiplatelet, NSAID, prostaglandin, H, synthase, blocks, thromboxane, synthesis, Cyclooxygenase, 4092, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
2 篇 Aspirin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Aspirin 的部分引用包括：
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
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Aspirin 的评论
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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