Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewATC 0175 hydrochloride
Discontinued Product
3346 has been discontinued.
View all Melanin-concentrating Hormone Receptors products.
说明： MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
化学名： N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for ATC 0175 hydrochloride
ATC 0175 hydrochloride is a potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT2B and 5-HT1A receptors (IC50 values are 9.66 and 16.9 nM respectively).
技术数据 for ATC 0175 hydrochloride
| 分子量 | 461.94 |
| 公式 | C23H25F2N5O.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 510733-97-8 |
| PubChem ID | 9934032 |
| InChI Key | HUUPKFUYSQNNLO-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC(F)=C(F)C=C4)N[C@@H](CC3)CC[C@@H]3NC2=NC1=CC=CC=C1C(N(C)C)=N2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ATC 0175 hydrochloride
参考文献 for ATC 0175 hydrochloride
参考文献是支持产品生物活性的出版物。
Chaki et al (2005) Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J.Pharmacol.Exp.Ther. 313 831 PMID: 15677346
Chaki et al (2005) ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 11 341 PMID: 16614734
按标靶查看相关产品
关键词: ATC 0175 hydrochloride, ATC 0175 hydrochloride supplier, MCH1, melanin, concentrating, hormone, receptors, 5-HT, serotonin, antagonists, ATC0175, hydrochloride, 5-HT2b, 5-HT1a, partial, MCHR1, MCH1R, Melanin-concentrating, Hormone, Receptors, 5-HT2B, 5-HT1A, 3346, Tocris Bioscience
ATC 0175 hydrochloride 的评论
目前没有该产品的评论。 Be the first to review ATC 0175 hydrochloride and earn rewards!
Have you used ATC 0175 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.