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Submit ReviewAvasimibe
说明： ACAT inhibitor
化学名： 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
纯度： ≥98% (HPLC)
生物活性 for Avasimibe
Avasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for Avasimibe
Avasimibe is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Avasimibe
| 分子量 | 501.72 |
| 公式 | C29H43NO4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 166518-60-1 |
| PubChem ID | 166558 |
| InChI Key | PTQXTEKSNBVPQJ-UHFFFAOYSA-N |
| Smiles | CC(C1=CC(C(C)C)=C(C(C(C)C)=C1)CC(NS(=O)(OC2=C(C(C)C)C=CC=C2C(C)C)=O)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Avasimibe
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 50.17 | 100 | |
| ethanol | 10.03 | 20 |
制备储备液 for Avasimibe
以下数据基于产品分子量 501.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.97 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for Avasimibe
参考文献 for Avasimibe
参考文献是支持产品生物活性的出版物。
Lee et al (1996) Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J.Med.Chem. 39 5031 PMID: 8978833
Yang et al (2016) Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature 531 651 PMID: 26982734
Li et al (2016) Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene 35 6378 PMID: 27132508
If you know of a relevant reference for Avasimibe, please let us know.
关键词: Avasimibe, Avasimibe supplier, CI-1011, ACAT, inhibits, inhibitors, acyl-CoA:cholesterol, O-acyl, transferase, antitumor, Acyl-CoAcholesterol, acyltransferase, Acyl-CoA:Cholesterol, Acyltransferase, 6505, Tocris Bioscience
篇 Avasimibe 的引用文献
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Avasimibe 的评论
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