Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAZ 3451
说明： Potent negative allosteric modulator of PAR2 receptors
化学名： 2-(6-Bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide
纯度： ≥98% (HPLC)
生物活性 for AZ 3451
AZ 3451 is a potent negative allosteric modulator of PAR2 (IC50 = 23 nM); binds to a remote allosteric site outside the helical bundle. Inhibits ERK phosphorylation in 1321N1 cells overexpressing wild-type human PAR2. Highly lipophilic.
化合物库 for AZ 3451
AZ 3451 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for AZ 3451
| 分子量 | 571.46 |
| 公式 | C30H27BrN4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2100284-59-9 |
| PubChem ID | 126961335 |
| InChI Key | FJAOGFGHTPYADT-SFHVURJKSA-N |
| Smiles | C[C@H](N1C2=CC=C(C(NC3=CC=C(C#N)C=C3)=O)C=C2N=C1C4=C(C=C5OCOC5=C4)Br)C6CCCCC6 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for AZ 3451
参考文献 for AZ 3451
参考文献是支持产品生物活性的出版物。
Cheng et al (2017) Structural insight into allosteric modulation of protease-activated receptor 2. Nature 545 112 PMID: 28445455
按产品操作查看相关产品
关键词: AZ 3451, AZ 3451 supplier, AZ3451, Potent, negative, allosteric, modulators, PAR2, antagonists, antagonism, F2R, like, trypsin, receptor, 1, protease-activated, Protease-Activated, Receptors, 6806, Tocris Bioscience
AZ 3451 的评论
目前没有该产品的评论。 Be the first to review AZ 3451 and earn rewards!
Have you used AZ 3451?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image