AZ 6102

Cat. No. 5775 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent TNKS1/2 inhibitor

化学名： rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for AZ 6102

AZ 6102 is a potent TNKS2 and TNKS1 inhibitor (IC₅₀ values are 1 and 3 nM, respectively). Exhibits >100-fold selectivity for TNKS1/2 over PARP-1, PARP-2 and PARP-6. Inhibits Wnt signaling in DLD-1 cells (IC₅₀ = 5 nM). Exhibits moderate oral bioavailability.

External Portal Information for AZ 6102

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AZ6102 is reviewed on the chemical probes website.

化合物库 for AZ 6102

AZ 6102 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AZ 6102

分子量	428.53
公式	C₂₅H₂₈N₆O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1645286-75-4
PubChem ID	91663328
InChI Key	WCPTUQOMNJBIET-CALCHBBNSA-N
Smiles	CC1=CC(N2C[C@H](C)N[C@H](C)C2)=NC=C1C3=CC=C(C(N4)=NC5=C(C=CN5C)C4=O)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZ 6102

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	21.43	50

制备储备液 for AZ 6102

以下数据基于产品分子量 428.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.67 mL	23.34 mL	46.67 mL
2.5 mM	0.93 mL	4.67 mL	9.33 mL
5 mM	0.47 mL	2.33 mL	4.67 mL
25 mM	0.09 mL	0.47 mL	0.93 mL

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产品说明书 for AZ 6102

分析证书/产品说明书

化学品安全技术说明书

参考文献 for AZ 6102

参考文献是支持产品生物活性的出版物。

Johannes et al (2015) Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med.Chem.Lett. 13 254 PMID: 25815142

If you know of a relevant reference for AZ 6102, please let us know.

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关键词: AZ 6102, AZ 6102 supplier, AZ6102, potent, selective, TNKS1, TNKS2, inhibitors, inhibits, tankyrases, Wnt, signaling, Tankyrase, 5775, Tocris Bioscience

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Stem Cell Research Product Guide

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