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Submit ReviewAZD 1283
说明： High affinity P2Y12 antagonist
化学名： Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
纯度： ≥98% (HPLC)
生物活性 for AZD 1283
AZD 1283 is a potent and high affinity P2Y12 antagonist (IC50 = 11 nM in radioligand competition binding assay, and 25 nM in a GTPγS binding assay). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.
化合物库 for AZD 1283
AZD 1283 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for AZD 1283
| 分子量 | 470.54 |
| 公式 | C23H26N4O5S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 919351-41-0 |
| PubChem ID | 23649325 |
| InChI Key | NEMHKCNXXRQYRF-UHFFFAOYSA-N |
| Smiles | CCOC(C1=CC(C#N)=C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)N=C1C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for AZD 1283
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 47.05 | 100 |
制备储备液 for AZD 1283
以下数据基于产品分子量 470.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.13 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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产品说明书 for AZD 1283
参考文献 for AZD 1283
参考文献是支持产品生物活性的出版物。
Bach et al (2013) Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J.Med.Chem. 56 7015 PMID: 23899349
Zhang et al (2014) Agonist-bound structure of the human P2Y12 receptor. Nature 509 119 PMID: 24784220
Zhang et al (2014) Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 509 115 PMID: 24670650
If you know of a relevant reference for AZD 1283, please let us know.
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关键词: AZD 1283, AZD 1283 supplier, AZD1283, High, affinity, p2y12, purine, receptors, antagonists, purinoceptors, purinergic, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 6085, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.