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AZD 3988

Cat. No. 4837 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective DGAT-1 inhibitor
化学名： trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 3988

AZD 3988 is a potent and selective diacylglycerol acyltransferase (DGAT-1) inhibitor (IC50 = 0.6 nM). Exhibits selectivity for DGAT-1 over DGAT-2, Kv11.1 (hERG) and cytochrome P450 enzymes. Suppresses triacylglyceride (TAG) plasma excursion and adipose tissue TAG synthesis in rats. Reduces body weight of diet-induced obese rats. Cell permeable and orally bioavailable.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

化合物库 for AZD 3988

AZD 3988 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for AZD 3988

分子量 456.44
公式 C23H22F2N4O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 892489-52-0
PubChem ID 23648867
InChI Key NGEBYTLALFOQKI-UHFFFAOYSA-N
Smiles O=C(NC3=CC=[C@@]([C@H]4CC[C@H](CC(O)=O)CC4)C=C3)C1=NN=C(NC2=CC(F)=C(F)C=C2)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 3988

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.64 100
1eq. NaOH 4.56 10 温和加热

制备储备液 for AZD 3988

以下数据基于产品分子量 456.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.95 mL 21.91 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.1 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for AZD 3988

参考文献是支持产品生物活性的出版物。

McCoull et al (2012) Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg.Med.Chem.Lett. 22 3873 PMID: 22608962

If you know of a relevant reference for AZD 3988, please let us know.

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关键词: AZD 3988, AZD 3988 supplier, AZD3988, potent, selective, diacylglycerol, transferases, DGAT1, inhibitors, inhibits, obesity, orally, bioavailable, cell, permeable, Diacylglycerol, O-Acyltransferase, 4837, Tocris Bioscience

3 篇 AZD 3988 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AZD 3988 的部分引用包括：

Mahoney et al (2019) A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition. Nat Commun 10 96 PMID: 30626880

Andris et al (2022) Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Rep 39 110995 PMID: 35732120

Benedikt M et al (2019) A Novel Role for Triglyceride Metabolism in Foxp3 Expression. Front Immunol 10 1860 PMID: 31456800

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