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Submit ReviewAzurin p28 peptide
说明： Increases p53 levels; binds p53 and inhibits COP1-mediated ubiquitination of p53
纯度： ≥95% (HPLC)
生物活性 for Azurin p28 peptide
Azurin p28 peptide is a 28 amino acid fragment of azurin (amino acids 50-77). The peptide is preferentially taken up by human breast cancer cell lines via caveolin-mediated endocytosis. Azurin p28 peptide binds wild-type and mutant p53 protein and inhibits E3 ligase COP1-mediated ubiquitination of p53 by >80%, resulting in decreased proteasomal degradation of p53. It induces cell cycle arrest in the G2/M phase leading to apoptosis. Azurin p28 peptide exhibits antiproliferative effects in human breast cancer cells in vitro and in vivo.
技术数据 for Azurin p28 peptide
| 分子量 | 2914.2 |
| 公式 | C122H197N31O47S2 |
| 序列 | LSTAADMQGVVTDGMASGLDKDYLKPDD |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 897026-25-4 |
| PubChem ID | 53363312 |
| InChI Key | RFGPECAMUVWTJN-AWHPYGDNSA-N |
| Smiles | O=C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Azurin p28 peptide
参考文献 for Azurin p28 peptide
参考文献是支持产品生物活性的出版物。
Yaghoubi et al (2020) p28 bacterial peptide, as an anticancer agent. Front.Oncol. 10 1303 PMID: 32850408
Yamada et al (2013) p28, a first in class peptide inhibitor of cop1 binding to p53. Br.J.Cancer 108 2495 PMID: 23736031
Yamada et al (2009) A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells. Mol.Cancer Ther. 8 2947 PMID: 19808975
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关键词: Azurin p28 peptide, Azurin p28 peptide supplier, p53, binding, binds, COP1, E3, ligase, inhibitors, inhibits, breast, cancer, antiproliferative, tp53, Ubiquitin, Ligases, 7662, Tocris Bioscience
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Pathways for Azurin p28 peptide
