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BAM (8-22)

Cat. No. 1763 5 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent MRGPRX1 agonist
纯度： ≥95% (HPLC)
说明书
引用文献 (5)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAM (8-22)

BAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.

技术数据 for BAM (8-22)

分子量 1971.22
公式 C91H127N25O23S
序列 VGRPEWWMDYQKRYG
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 412961-36-5
PubChem ID 16158367
InChI Key GOEYECACIBFJGZ-NPAGUKBMSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAM (8-22)

溶解性 Soluble to 1 mg/ml in water

产品说明书 for BAM (8-22)

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化学品安全技术说明书

参考文献 for BAM (8-22)

参考文献是支持产品生物活性的出版物。

Chen and Ikeda (2004) Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 24 5044 PMID: 15163697

Lembo et al (2002) Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 5 201 PMID: 11850634

Simonin and Kieffer (2002) Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 5 185 PMID: 11865303

Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev 66 570 PMID: 24867890

Sanjel et al (2019) BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci.Rep. 9 10888 PMID: 31350433

Sun et al (2016) Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Am.J.Transl.Res. 8 1144 PMID: 27158400

If you know of a relevant reference for BAM (8-22), please let us know.

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关键词: BAM (8-22), BAM (8-22) supplier, Selective, agonists, sensory, neuron-specific, receptors, SNSR, MRGPRX1, mas-related, g, protein, coupled, agonism, potent, Mas-related, G, Protein-Coupled, Receptors, 1763, Tocris Bioscience

5 篇 BAM (8-22) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAM (8-22) 的部分引用包括：

Grundy et al (2021) Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension. J.Neurosci. 41 3900 PMID: 33727332

Moser and Giesler (2013) Itch and analgesia resulting from intrathecal application of morphine: contrasting effects on different populations of trigeminothalamic tract neurons. J Neurosci 33 6093 PMID: 23554490

Sanjel et al (2019) BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci.Rep. 9 10888 PMID: 31350433

Honda et al (2019) Effects of intravesical administration of sensory neuron-specific receptor agonist on voiding function in rats with CP-induced cystitis. Cent European J Urol 72 142 PMID: 31482020

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BAM (8-22) 的评论

平均评分: 5 (Based on 1 Review.)

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Excellent In vivo and ex vivo activity with miminal lot variation.
By Jeff Guo on 11/30/2023
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Dorsal Root Ganglia

Demonstrates excellent bio-activity and virtually free of batch/lot-effects in both in vivo mouse behavioral assays (low mM concentrations) and ex vivo calcium imaging assays (low μM concentrations). Highly recommended to minimize variation, for critical assays, and for generating publication quality data.Attached image shows representative calcium response of ex vivo dorsal root ganglia in response to bath applied 10 μM BAM 8-22. Image is composite of GCaMP3 fluorescence intensity over 180 seconds, after baseline subtraction, with contract and brightness adjustments to improve image clarity.

review image