Mas-Related G Protein-Coupled Receptors

Mas-related G protein-coupled receptors (MRGPRs) are a family of orphan GPCRs, subdivided into nine separate subfamilies (A-H and X). They are found in mammalian species, with families A, B, C and H present only in rodents, the X subfamily only in primates, including humans, and families D to G conserved across mammalian species. The MRGPRX family consists of four distinct receptors: MRGPRX1 was previously known as sensory neuron-specific receptor (SNSR) 4 and MRGPRX3 was previously named SNSR1.

MRGPRs are expressed in small-diameter somatosensory neurons of the dorsal root ganglion, MRGPRD to H are also expressed in other neurons, as well as bladder, testis, uterus, arteries, intestines and adrenal glands, and MRGPRX1 and 2 are also expressed in mast cells. This receptor family is important in pain, temperature sensation and itch. While no MRGPRs have officially been deorphanized several endogenous and exogenous compounds are known to be ligands for certain receptors in this family.

External sources of pharmacological information for Mas-Related G Protein-Coupled Receptors :

• BJP Guide

Mas-Related G Protein-Coupled Receptor Gene Data