Batimastat

Name: Batimastat
Brand: Tocris Bioscience
SKU: 2961
Rating: 4 (1 reviews)

Cat. No. 2961 29 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, broad spectrum MMP inhibitor

别名： BB-94

化学名： (2R,3S)-N⁴-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide

纯度： ≥99% (HPLC)

说明书

引用文献 (29)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Batimastat

Batimastat is a potent, broad spectrum MMP inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.

技术数据 for Batimastat

分子量	477.64
公式	C₂₃H₃₁N₃O₄S₂
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	130370-60-4
PubChem ID	5362422
InChI Key	XFILPEOLDIKJHX-QYZOEREBSA-N
Smiles	O=[C@]([C@H](CC(C)C)[C@@H]([C@](NO)=O)CSC2=CC=CS2)N[C@H](C(NC)=O)CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Batimastat

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	47.76	100

制备储备液 for Batimastat

以下数据基于产品分子量 477.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL
10 mM	0.21 mL	1.05 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for Batimastat

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Batimastat

参考文献是支持产品生物活性的出版物。

Davies et al (1993) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 53 2087 PMID: 8347186

Wang et al (1994) Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54 4726 PMID: 8062271

Kohn and Liotta (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55 1856 PMID: 7728753

If you know of a relevant reference for Batimastat, please let us know.

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