主页 / 药理学 / Enzymes / Cyclases / Guanylyl Cyclases / Guanylyl Cyclase Activators / BAY 41-2272

BAY 41-2272

Cat. No. 4430 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Soluble guanylyl cyclase (sGC) activator
化学名： 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 41-2272

BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

化合物库 for BAY 41-2272

BAY 41-2272 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BAY 41-2272

分子量 360.39
公式 C20H17FN6
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 256376-24-6
PubChem ID 9798973
InChI Key ATOAHNRJAXSBOR-UHFFFAOYSA-N
Smiles FC(C=CC=C3)=C3CN2N=C(C4=NC=C(C5CC5)C(N)=N4)C1=CC=CN=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 41-2272

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.04 100

制备储备液 for BAY 41-2272

以下数据基于产品分子量 360.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for BAY 41-2272

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BAY 41-2272

参考文献是支持产品生物活性的出版物。

Stasch et al (2010) NO-independent regulatory site on soluble guanylate cyclase. Nature 410 212 PMID: 11242081

Joshi et al (2011) The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 339 394 PMID: 21825001

Mittendorf et al (2009) Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 4 853 PMID: 19263460

If you know of a relevant reference for BAY 41-2272, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Guanylyl Cyclase Activators

关键词: BAY 41-2272, BAY 41-2272 supplier, activators, soluble, guanylyl, guanylate, cyclases, sGC, BAY41-2272, Guanylyl, Cyclase, Other, Nitric, Oxide, Enzyme, Substrates, /, Activators, 4430, Tocris Bioscience

1 篇 BAY 41-2272 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAY 41-2272 的部分引用包括：

Aly et al (2019) Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling. Cell Rep 27 1769-1780.e4 PMID: 31067462

您是否知道使用了 Tocris BAY 41-2272 的优秀论文？ 请告知我们.

BAY 41-2272 的评论

目前没有该产品的评论。 Be the first to review BAY 41-2272 and earn rewards!

Have you used BAY 41-2272?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review