BAY 598

Cat. No. 5991 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective SMYD2 inhibitor

化学名： N-[(4S)-1-[(Cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BAY 598

BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC₅₀ values are 27 and 58 nM for biochemical and cellular activity assays, respectively), which displays >100-fold selectivity for SMYD2 over a panel of 32 other methyltransferases including SMYD3, SUV420H1, and SUV420H2. BAY 598 enhances apoptotic responses to doxorubicin (Cat. No. 2252) in cancer cell lines, and decreases p53K370me levels in HEK293 cells. It also reduces methylation in tumor cells in a mouse xenograft model.

To request the negative control for BAY 598, please fill out the BAY 369 request form on the SGC website.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 598 probe summary on the SGC website.

External Portal Information for BAY 598

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 598 is reviewed on the chemical probes website.

化合物库 for BAY 598

BAY 598 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BAY 598

分子量	525.34
公式	C₂₂H₂₀Cl₂F₂N₆O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1906919-67-2
PubChem ID	117072551
InChI Key	OTTJIRVZJJGFTK-SFHVURJKSA-N
Smiles	CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC(OC(F)F)=CC=C2)=N\C#N)N=C1C3=CC(Cl)=C(C=C3)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 598

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	52.53	100

制备储备液 for BAY 598

以下数据基于产品分子量 525.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.9 mL	9.52 mL	19.04 mL
5 mM	0.38 mL	1.9 mL	3.81 mL
10 mM	0.19 mL	0.95 mL	1.9 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for BAY 598

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BAY 598

参考文献是支持产品生物活性的出版物。

Eggert et al (2016) Discovery and characterization of a highly potent and selective aminopyrazoline-based in vivo probe (BAY-598) for the protein lysine methyltransferase SMYD2. J.Med.Chem. 59 4578 PMID: 27075367

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 10 19 PMID: 30604761

If you know of a relevant reference for BAY 598, please let us know.

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关键词: BAY 598, BAY 598 supplier, BAY598, lysine, methyltransferase, inhibitors, inhibits, potent, selective, SMYD2, SET, and, MYND, domain, contain, protein, 2, Other, Lysine, Methyltransferases, 5991, Tocris Bioscience

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