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BAY 678

Cat. No. 5706 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor
化学名： 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 678

BAY 678 is a potent and selective cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM). Exhibits around 2000-fold selectivity for NHE against a panel of 21 other serine proteases. Effective in an acute lung injury model in vivo. Orally bioavailable. Inactive S-enantiomer (Cat.No.6389) also available.

许可信息

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 678 probe summary on the SGC website.

技术数据 for BAY 678

分子量 400.35
公式 C20H15F3N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 675103-36-3
PubChem ID 23728722
InChI Key PGIVGIFOWOVINL-GOSISDBHSA-N
Smiles CC(C([C@H]1C2=CN=C(C#N)C=C2)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C(N1)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 678

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.03 100

制备储备液 for BAY 678

以下数据基于产品分子量 400.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.98 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for BAY 678

参考文献是支持产品生物活性的出版物。

von Nussbaum et al (2015) Freezing the bioactive conformation to boost potency: The identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases. ChemMedChem. 10 1163 PMID: 26083237

If you know of a relevant reference for BAY 678, please let us know.

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关键词: BAY 678, BAY 678 supplier, BAY678, human, neutrophil, elastase, inhibitors, inhibits, HNE, orally, bioavailable, cell, permeable, potent, selective, Elastase, 5706, Tocris Bioscience

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