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BAY 826

Cat. No. 6579 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent Tie2 inhibitor
化学名： [3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BAY 826

BAY 826 is a potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.

Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.

External Portal Information for BAY 826

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.

化合物库 for BAY 826

BAY 826 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BAY 826

分子量 558.53
公式 C26H19F5N6OS
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1448316-08-2
PubChem ID 71623052
InChI Key MPASHPJAIUOWCK-UHFFFAOYSA-N
Smiles CC1=CC(C)=C(C=C1N2C=CN3N=C(C4=CN=CC=C4)C=C23)NC(C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BAY 826

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100
ethanol 100

制备储备液 for BAY 826

以下数据基于产品分子量 558.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.95 mL 17.9 mL
5 mM 0.36 mL 1.79 mL 3.58 mL
10 mM 0.18 mL 0.9 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Molarity Calculator

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参考文献 for BAY 826

参考文献是支持产品生物活性的出版物。

Schneider et al (2017) Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J.Neurochem. 140 170 PMID: 27787897

If you know of a relevant reference for BAY 826, please let us know.

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关键词: BAY 826, BAY 826 supplier, BAY826, TEK, tyrosine, kinase, Tie, 2, angiopoietin, 1, receptor, inhibitors, inhibits, Other, RTKs, 6579, Tocris Bioscience

1 篇 BAY 826 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BAY 826 的部分引用包括：

Stephanie et al (2022) Angiopoietin-1 Upregulates Cancer Cell Motility in Colorectal Cancer Liver Metastases through Actin-Related Protein 2/3. Cancers (Basel) 14 PMID: 35626145

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BAY 826 的评论

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