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Submit ReviewBAZ2-ICR
说明： Selective BAZ2 inhibitor
化学名： 4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
纯度： ≥98% (HPLC)
生物活性 for BAZ2-ICR
BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (IC50 values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.
External Portal Information for BAZ2-ICR
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.
化合物库 for BAZ2-ICR
BAZ2-ICR is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BAZ2-ICR
| 分子量 | 357.41 |
| 公式 | C20H19N7 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1665195-94-7 |
| PubChem ID | 91654625 |
| InChI Key | RRZVGDGTWNQAPW-UHFFFAOYSA-N |
| Smiles | CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BAZ2-ICR
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.74 | 100 | |
| ethanol | 35.74 | 100 |
制备储备液 for BAZ2-ICR
以下数据基于产品分子量 357.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for BAZ2-ICR
参考文献 for BAZ2-ICR
参考文献是支持产品生物活性的出版物。
Drouin et al (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem. 58 2553 PMID: 25719566
If you know of a relevant reference for BAZ2-ICR, please let us know.
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关键词: BAZ2-ICR, BAZ2-ICR supplier, BAZ2-ICR, selective, baz2, bromodomains, inhibitors, inhibits, BAZ2A, BAZ2B, epigenetics, SGC, structural, genomics, consortium, Bromodomains, 5266, Tocris Bioscience
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