BC 11 hydrobromide

Name: BC 11 hydrobromide
Brand: Tocris Bioscience
SKU: 4372
Rating: 4 (1 reviews)

Cat. No. 4372 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective urokinase (uPA) inhibitor

化学名： Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide

说明书

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BC 11 hydrobromide

BC 11 hydrobromide is a selective urokinase (uPA) inhibitor (IC₅₀ = 8.2 μM). Exhibits no activity at 8 other related enzymes. Inhibits clot lysis with no effect on clot formation. Also decreases viability of MDA-MB231 breast cancer cells in vitro.

技术数据 for BC 11 hydrobromide

分子量	290.97
公式	C₈H₁₁BN₂O₂S.HBr
储存	Store at -20°C
CAS Number	443776-49-6
PubChem ID	78243712
InChI Key	PAFZAMOVHIRQOD-UHFFFAOYSA-N
Smiles	NC(SCC1=CC=C(B(O)O)C=C1)=N.Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BC 11 hydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	29.1	100
	water	5.82	20 温和加热

制备储备液 for BC 11 hydrobromide

以下数据基于产品分子量 290.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.44 mL	17.18 mL	34.37 mL
5 mM	0.69 mL	3.44 mL	6.87 mL
10 mM	0.34 mL	1.72 mL	3.44 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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产品说明书 for BC 11 hydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BC 11 hydrobromide

参考文献是支持产品生物活性的出版物。

Smith et al (2011) Elucidating novel urokinase-type plasminogen activator inhibitors. Int.Soc.Thromb.Haemost. (Abstract) 9 819

Longo et al (2015) Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells Molecules 20 9879 PMID: 26029857

If you know of a relevant reference for BC 11 hydrobromide, please let us know.

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关键词: BC 11 hydrobromide, BC 11 hydrobromide supplier, BC11, HBr, urokinase, inhibitor, inhibits, uPA, urokinase-type, plasminogen-activator, inhibitors, Urokinase, 4372, Tocris Bioscience

3 篇 BC 11 hydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BC 11 hydrobromide 的部分引用包括：

Semina et al (2016) Urokinase and urok. receptor participate in regulation of neuronal migration, axon growth and branching. Eur.J.Cell Biol. 95 295 PMID: 27324124

Keasey et al (2018) Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling. J Cell Sci 131 PMID: 29222114

Magnussen et al (2017) Cleavage of the urok. receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer 17 350 PMID: 28526008

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