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BC-LI-0186

Cat. No. 6791 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor
化学名： 4-[2,5-Dihydro-2,3-dimethyl-4-(1-methylethyl)-5-oxo-1H-pyrazol-1-yl]-N-(2-phenoxyethyl)benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BC-LI-0186

BC-LI-0186 is a potent and high affinity leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor (IC50 = 46.1 nM; Kd = 42.1 nM for binding to LRS). Inhibits mTOR complex 1 activity by blocking binding to LRS without affecting catalytic activity. Inhibits leucine-induced translocation of LRS to the lysosome.

化合物库 for BC-LI-0186

BC-LI-0186 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BC-LI-0186

分子量 429.54
公式 C22H27N3O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 695207-56-8
PubChem ID 4917788
InChI Key SQYWMHPZMHDCHP-UHFFFAOYSA-N
Smiles CC(C1=C(N(N(C2=CC=C(S(=O)(NCCOC3=CC=CC=C3)=O)C=C2)C1=O)C)C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BC-LI-0186

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.95 100

制备储备液 for BC-LI-0186

以下数据基于产品分子量 429.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for BC-LI-0186

参考文献是支持产品生物活性的出版物。

Kim et al (2017) Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction. Nat.Commun. 8 732 PMID: 28963468

Choi et al (2017) Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane. Biochem.Biophys.Res.Commun. 493 1129 PMID: 28882589

Lee et al (2018) Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway. Proc.Natl.Acad.Sci.USA. 115 E5279 PMID: 29784813

If you know of a relevant reference for BC-LI-0186, please let us know.

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关键词: BC-LI-0186, BC-LI-0186 supplier, Leucyl-RNA, synthase, TRS, RagD, GTPase, interaction, inhibitor, mTOR, complex, translocation, lysosome, Other, Synthases/Synthetases, Ras, GTPases, 6791, Tocris Bioscience

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