Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBCTC
说明： TRPV1 antagonist
化学名： 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for BCTC
BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.
化合物库 for BCTC
BCTC is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BCTC
| 分子量 | 372.89 |
| 公式 | C20H25ClN4O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 393514-24-4 |
| PubChem ID | 9929425 |
| InChI Key | ROGUAPYLUCHQGK-UHFFFAOYSA-N |
| Smiles | ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BCTC
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 37.29 | 100 | |
| ethanol | 14.92 | 40 |
制备储备液 for BCTC
以下数据基于产品分子量 372.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.41 mL | 26.82 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for BCTC
参考文献 for BCTC
参考文献是支持产品生物活性的出版物。
Pomonis et al (2003) N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflamma J.Pharmacol.Exp.Ther. 306 387 PMID: 12721336
Valenzano et al (2003) N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic proper J.Pharmacol.Exp.Ther. 306 377 PMID: 12721338
If you know of a relevant reference for BCTC, please let us know.
按产品操作查看相关产品
关键词: BCTC, BCTC supplier, vanilloid, trpv1, antagonists, transient, receptors, potential, channels, TRPV, 3875, Tocris Bioscience
2 篇 BCTC 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BCTC 的部分引用包括：
Lian et al (2017) Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis. Mol Med Rep 16 1920 PMID: 28627595
Lars et al (2014) Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis. J Clin Invest 124 3793-806 PMID: 25083990
您是否知道使用了 Tocris BCTC 的优秀论文？ 请告知我们.
BCTC 的评论
目前没有该产品的评论。 Be the first to review BCTC and earn rewards!
Have you used BCTC?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image