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Bengamide B

Cat. No. 5273 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5273 has been discontinued.

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说明： Potent inhibitor of NF-κB activation
化学名： (6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-D-gulo-Non-6-enonamide
纯度： ≥97% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Bengamide B

Bengamide B is a potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.

技术数据 for Bengamide B

分子量 598.81
公式 C32H58N2O8
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 104947-69-5
PubChem ID 6444128
InChI Key PFRKTXMXGDERHT-UCDUEDMDSA-N
Smiles O=C1N(C)C[C@@H](OC(CCCCCCCCCCCCC)=O)CC[C@@H]1NC([C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Bengamide B

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参考文献 for Bengamide B

参考文献是支持产品生物活性的出版物。

Hu et al (2007) Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 14 764 PMID: 17656313

Johnson et al (2012) Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg.Med.Chem. 20 4348 PMID: 22705020

Kinder et al (2001) Synthesis and antitumor activity of ester-modified analogues of bengamide B. J.Med.Chem. 44 3692 PMID: 11606134

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关键词: Bengamide B, Bengamide B supplier, Methionyl, aminopeptidase, MetAP1, MetAP2, potent, NF-κB, inhibitors, nuclear, factor, kappa, B, anti-inflammatory, antitumor, antitumour, inhibits, NF-kB/IkB, 5273, Tocris Bioscience

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Pathways for Bengamide B

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.