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BGC 20-1531 hydrochloride

Cat. No. 5327 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity and selective EP4 antagonist
别名： PGN 1531
化学名： 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BGC 20-1531 hydrochloride

BGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

化合物库 for BGC 20-1531 hydrochloride

BGC 20-1531 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BGC 20-1531 hydrochloride

分子量 529
公式 C26H24N2O6S.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1962928-26-2
PubChem ID 121513858
InChI Key ZSHYZCXOFPPBMH-UHFFFAOYSA-N
Smiles CC(OC(C(NS(C4=CC=CC=C4C)(=O)=O)=O)=C3)=C3COC(C=C2)=CC=C2C1=NC=C(OC)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BGC 20-1531 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.25 100

制备储备液 for BGC 20-1531 hydrochloride

以下数据基于产品分子量 529。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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产品说明书 for BGC 20-1531 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for BGC 20-1531 hydrochloride

参考文献是支持产品生物活性的出版物。

Sutton et al (2014) From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg.Med.Chem.Lett. 24 2212 PMID: 24703233

If you know of a relevant reference for BGC 20-1531 hydrochloride, please let us know.

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关键词: BGC 20-1531 hydrochloride, BGC 20-1531 hydrochloride supplier, BGC20-1531, hydrochloride, PGN1531, high, affinity, selective, EP4, antagonists, orally, bioavailable, active, PGN, 1531, Prostanoid, Receptors, 5327, Tocris Bioscience

2 篇 BGC 20-1531 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BGC 20-1531 hydrochloride 的部分引用包括：

David et al (2022) Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer Discov 12 1904-1921 PMID: 35552618

Perkins et al (2018) Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat.Immunol. 19 1309 PMID: 30397349

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