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Discontinued Product
1236 has been discontinued.
说明： Inhibitor of SERCA ATPase
化学名： 1,4-Dihydroxy-2,5-di-tert-butylbenzene
生物活性 for BHQ
BHQ is a selective inhibitor of endoplasmic reticulum Ca2+-ATPase.
技术数据 for BHQ
| 分子量 | 222.33 |
| 公式 | C14H22O2 |
| 储存 | Store at RT |
| CAS Number | 88-58-4 |
| PubChem ID | 2374 |
| InChI Key | JZODKRWQWUWGCD-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=CC(O)=C(C=C1O)C(C)(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BHQ
参考文献 for BHQ
参考文献是支持产品生物活性的出版物。
Dettbarn and Palade (1999) Effects of three sarcoplasmic/endoplasmic Ca++ pump inhibitors on release channels and intracellular stores. J.Pharmacol.Exp.Ther. 285 739 PMID: 9580621
Fusi et al (1999) 2,5-Di-t-butyl-1,4 benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur.J.Pharmacol. 366 181 PMID: 10082199
Hassessian et al (1994) Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ). Br.J.Pharmacol. 112 1118 PMID: 7952872
Jan et al (1999) Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells. Eur.J.Pharmacol. 365 111 PMID: 9988129
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关键词: BHQ, BHQ supplier, inhibitors, inhibits, SERCA, ATPase, Ca2+, modulators, Ca2+-ATPase, Signaling, Signalling, Calcium, P-Type, ATPases, Calcium-ATPase, Ion, Transporters, Pumps, 1236, Tocris Bioscience
3 篇 BHQ 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BHQ 的部分引用包括：
Dai et al (2012) Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem 287 14586 PMID: 22418436
Inagaki et al (2014) Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca2+ channel due to a familial hemiplegic migraine mutation. Neuron 81 91 PMID: 24411734
Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903 PMID: 20820851
BHQ 的评论
平均评分: 4 (Based on 1 Review.)
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BHQ depletes ER Ca2+ store in HEK cells leading to STIM1-Orai1 clustering for store-operated Ca2+ entry..
By
Niroj Shrestha on 10/27/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK293
ER resident protein, STIM1 and PM resident Orai1 channel were expressed with YFP and CFP fluorescent tags respectively in HEK293 cells and imaged using TIRF microscopy. Basal STIM1 and Orai1 (left) co-clusters to form punctae at PM-ER junctions upon ER store depletion (right) by BHQ (30 µM), leading to store-operated Ca2+ entry through Orai1.
