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Submit ReviewBI 2852 FL 最新
说明： Pan RAS Tracer
化学名： N-(15-(5,5-Difluoro-7-(1H-pyrrol-2-yl)-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-13-oxo-3,6,9-trioxa-12-azapentadecyl)-5-(2-((6-((((3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indol-2-yl)methyl)amino)methyl)-1H-indol-1-yl)methyl)-1H-imidazol-1-yl)pentanamide
纯度： ≥95% (HPLC)
生物活性 for BI 2852 FL
BI 2852 FL is a cell-permeable pan-RAS bioluminescence resonance energy transfer (BRET) fluorescent probe. BI 2852 FL is synthesized by conjugating a fluorophore to a derivative of the reversible SI/II-P KRAS inhibitor, BI 2852. BI 2852 FL is used in competitive BRET format to quantify SII-P engagement to multimeric RAS complexes in live cells.
技术数据 for BI 2852 FL
| 分子量 | 1088.04 |
| 公式 | C59H64BF2N11O7 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2762758-95-0 |
| PubChem ID | 162640683 |
| InChI Key | VINGSJQDAYACET-UHFFFAOYSA-N |
| Smiles | O=C1NC(C2=CC(O)=CC=C12)C3=C(NC4=C3C=CC=C4)CNCC5=CC6=C(C=C5)C=CN6CC7=NC=CN7CCCCC(NCCOCCOCCOCCNC(CCC8=CC=C9C=C%10C=CC(C%11=CC=CN%11)=[N+]%10[B-](N98)(F)F)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BI 2852 FL
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.88 | 10 |
制备储备液 for BI 2852 FL
以下数据基于产品分子量 1088.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 9.19 mL | 45.95 mL | 91.91 mL |
| 0.5 mM | 1.84 mL | 9.19 mL | 18.38 mL |
| 1 mM | 0.92 mL | 4.6 mL | 9.19 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.84 mL |
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产品说明书 for BI 2852 FL
参考文献 for BI 2852 FL
参考文献是支持产品生物活性的出版物。
Vasta et al (2022) KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat.Chem.Biol. 18 596 PMID: 35314814
If you know of a relevant reference for BI 2852 FL, please let us know.
关键词: BI 2852 FL, BI 2852 FL supplier, BI2852FL, BI-2852, FL, fluorescent, probes, fluorescence, bioluminescence, resonance, energy, transfer, BRET, KRAS, Other, Fluorescent, Probes, Ras, GTPases, 8110, Tocris Bioscience
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Fluorescent Dyes and Probes Research Product GuideUpdated
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including Janelia Fluor® Dyes
- Fluorescent Probes for Advanced Microscopy and Live Cell Imaging
- Fluorescent Probes to Support In Vivo, Deep Tissue, and Bioluminescence Imaging
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- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
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