主页 / 药理学 / Enzymes / Proteases / Matrix Metalloproteases / Matrix Metalloprotease Inhibitors / BI 4394

BI 4394

Cat. No. 8842 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly potent and selective MMP-13 inhibitor
化学名： 2-Ethyl 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BI 4394

BI 4394 is a highly potent and selective MMP-13 inhibitor (IC50 = 1 nM). BI 4394 inhibits the degradation of isolated bovine nasal cartilage explants (IC50 = 31 nM). It shows high selectivity (>1000 fold) for MMP-13 over other MMPs. In vivo, BI 4394 decreases the mean arthritic score vs control in a murine model of rheumatoid arthritis, when administered at a dose of 100 mg/kg over a 14-day period. BI 4394 is orally bioavailable.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 4394 page on the SGC website.

技术数据 for BI 4394

分子量 446.46
公式 C24H22N4O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1222173-37-6
PubChem ID 45376872
InChI Key MMJPVSDTLGFIQW-UHFFFAOYSA-N
Smiles O=C(O)C1=CC=C(C=C1)CNC(=O)C2=NN(C(=C2)C=3C=CC=4NC(=CC4C3)C(=O)OCC)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BI 4394

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.65 100

制备储备液 for BI 4394

以下数据基于产品分子量 446.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.4 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for BI 4394

参考文献是支持产品生物活性的出版物。

Taylor et al (2011) Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. J.Med.Chem. 54 8174 PMID: 22017539

Taylor et al (2021) Indole inhibitors of MMP-13 for arthritic disorders. ACS Omega 6 18635 PMID: 34337203

If you know of a relevant reference for BI 4394, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Matrix Metalloprotease Inhibitors

关键词: BI 4394, BI 4394 supplier, BI4394, potent, selective, inhibitors, inhibits, MMP13, Matrixins, Matrix, Metalloproteinase, MMP, Metalloprotease, proteinases, Proteases, orally, bioavailable, in, vivo, 8842, Tocris Bioscience

篇 BI 4394 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 BI 4394 的引用文献。 您是否知道使用了 Tocris BI 4394 的优秀论文？ 请告知我们.

BI 4394 的评论

目前没有该产品的评论。 Be the first to review BI 4394 and earn rewards!

Have you used BI 4394?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.