BIBP 3226 trifluoroacetate

Cat. No. 2707 14 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Mixed NPY Y₁ and NPFF receptor antagonist

化学名： N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamide trifluoroacetate

纯度： ≥98% (HPLC)

引用文献 (14)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BIBP 3226 trifluoroacetate

BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y₁ (NPY Y₁) and neuropeptide FF (NPFF) receptor antagonist (K_i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y₁, hNPFF₂, rNPFF, rNPY Y₂, rNPY Y₄ and rNPY Y₅ respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.

Important Information for BIBP 3226 trifluoroacetate

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis

技术数据 for BIBP 3226 trifluoroacetate

M. Wt	473.57 (Free Base)
公式	C₂₇H₃₁N₅O₃.xCF₃CO₂H
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	121513845
InChI Key	FSBMUMHPXBMVJF-MQWQBNKOSA-N
Smiles	OC1=CC=C(CNC([C@H](NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CCCNC(N)=N)=O)C=C1.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIBP 3226 trifluoroacetate

溶解性	Soluble to 1 mg/ml in water and to 50 mg/ml in DMSO

产品说明书 for BIBP 3226 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BIBP 3226 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Kask et al (1996) Anxiogenic-like effect of the neuropeptide Y Y₁ receptor antagonist BIBP3226: antagonism with D.pam. Eur.J.Pharmacol. 317 R3 PMID: 8997632

Mollereau et al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1 PMID: 11325787

Fang et al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207 PMID: 16762456

If you know of a relevant reference for BIBP 3226 trifluoroacetate, please let us know.

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关键词: BIBP 3226 trifluoroacetate, BIBP 3226 trifluoroacetate supplier, Mixed, NPFF, NPY, Y1, receptor, antagonists, Receptors, Neuropeptide, FF/AF, Y, BIBP3226, trifluoroacetate, npffr1, npffr2, npff1, npff2, neuropeptides, 2707, Tocris Bioscience

14 篇 BIBP 3226 trifluoroacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIBP 3226 trifluoroacetate 的部分引用包括：

Acton et al (2019) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep 28 625 PMID: 31315043

Aveleira et al (2015) Neuropeptide Y stimulates autophagy in hypothalamic neurons. Cell Death Dis 112 E1642 PMID: 25775546

Sparrow et al (2012) Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Proc Natl Acad Sci U S A 37 1409 PMID: 22218088

Santos-Carvalho et al (2013) Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate. Proc Natl Acad Sci U S A 4 e636 PMID: 23681231

Martins et al (2015) Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro. ASN Neuro 7 PMID: 26311075

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545 PMID: 25751534

Son et al (2011) Involvement of neuropeptide Y and its Y1 and Y5 receptors in maintaining self-renewal and proliferation of human embryonic stem cells. J Cell Mol Med 15 152 PMID: 19874423

Reidelberger et al (2013) Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats. Am J Physiol Endocrinol Metab 304 E944 PMID: 23482449

Zacharia et al (2013) High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes. PLoS One 8 e65969 PMID: 23776582

Yi et al (2012) Glucocorticoid signaling in the arcuate nucleus modulates hepatic Ins sensitivity. Diabetes 61 339 PMID: 22210324

Novielli et al (2012) Pre-diabetes augments neuropeptide Y1- and α1-receptor control of basal hindlimb vascular tone in young ZDF rats. PLoS One 7 e46659 PMID: 23071607

Pleil et al (2012) Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. Neuropharmacology 62 1777 PMID: 22182779

Ahsan Raza (2017) HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience. Nat Commun 8 189 PMID: 28775269

Businaro et al (2018) Platelet Lysate-Derived Neuropeptide y Influences Migration and Angiogenesis of Human Adipose Tissue-Derived Stromal Cells. Sci Rep 8 14365 PMID: 30254326

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