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BIBR 1532

Cat. No. 2981 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective telomerase inhibitor
化学名： 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BIBR 1532

BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

化合物库 for BIBR 1532

BIBR 1532 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BIBR 1532

分子量 331.36
公式 C21H17NO3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 321674-73-1
PubChem ID 9927531
InChI Key PGFQXGLPJUCTOI-WYMLVPIESA-N
Smiles C/C(C2=CC1=CC=CC=C1C=C2)=C\C(NC3=C(C(O)=O)C=CC=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIBR 1532

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.14 100
ethanol 8.28 25

制备储备液 for BIBR 1532

以下数据基于产品分子量 331.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.18 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for BIBR 1532

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for BIBR 1532

参考文献是支持产品生物活性的出版物。

Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958 PMID: 11742973

Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003 PMID: 17603541

Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329 PMID: 18454043

If you know of a relevant reference for BIBR 1532, please let us know.

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关键词: BIBR 1532, BIBR 1532 supplier, Selective, telomerase, inhibitors, inhibits, BIBR1532, Telomerase, DNA,, RNA, and, Protein, Synthesis, 2981, Tocris Bioscience

2 篇 BIBR 1532 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIBR 1532 的部分引用包括：

Beyer et al (2016) Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res 118 856 PMID: 26699654

Farnung et al (2012) Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One 7 e35714 PMID: 22558207

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BIBR 1532 的评论

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Telomerase inhibitor in vitro.
By Maria Garcia Gonzalez on 07/12/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： H9C2

Used BIBR 1532 as telomerase inhibitor at 2.5 uM with reproducible but moderate effects (expected).