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Submit ReviewBifemelane hydrochloride
说明： Non-selective MAO inhibitor
化学名： 4-(2-Benzylphenoxy)-N-methylbutylamine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Bifemelane hydrochloride
Bifemelane hydrochloride is an antidepressant MAO inhibitor. Reverses catalepsy induced by Tetrabenazine (Cat. No. 2175) in mice and increases locomotor activity in MPTP-treated marmosets.
化合物库 for Bifemelane hydrochloride
Bifemelane hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Bifemelane hydrochloride
| 分子量 | 305.84 |
| 公式 | C18H23NO.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 62232-46-6 |
| PubChem ID | 43962 |
| InChI Key | MEAHDXWXNNDSAK-UHFFFAOYSA-N |
| Smiles | Cl.CNCCCCOC1=CC=CC=C1CC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Bifemelane hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 30.58 | 100 | |
| DMSO | 30.58 | 100 |
制备储备液 for Bifemelane hydrochloride
以下数据基于产品分子量 305.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.27 mL | 16.35 mL | 32.7 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.54 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.27 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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产品说明书 for Bifemelane hydrochloride
参考文献 for Bifemelane hydrochloride
参考文献是支持产品生物活性的出版物。
Naoi et al (1988) 4-(o-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(o-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J.Neurochem. 50 243 PMID: 3335842
Nomoto et al (1994) Effects of bifemelane on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset. Neurosci.Lett. 178 95 PMID: 7816348
Tobe et al (1981) Pharmacological evaluation of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride (MCl-2016), a new psychotropic drug with antidepressant activity. Arzneimittelforschung 31 1278 PMID: 7197535
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关键词: Bifemelane hydrochloride, Bifemelane hydrochloride supplier, MAO-A, MAO-B, inhibitors, inhibits, Monoamine, oxygenases, Oxidases, Oxidase, Adrenergic, Related, Compounds, Dopaminergic-Related, 5-HT-Related, 5-HT3, Receptors, 0767, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.