BIIE 0246 hydrochloride

Cat. No. 7377 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective and competitive non-peptide NPY Y₂ receptor antagonist; active in vivo

别名： BIIE 0246 2HCl,BIIE0246 2HCl

化学名： N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BIIE 0246 hydrochloride

BIIE 0246 hydrochloride is a potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y₂ receptor (IC₅₀ = 15 nM). Displays > 650-fold selectivity for NPY Y₂ over Y₁, Y₄ and Y₅ receptors. Active in vivo.

技术数据 for BIIE 0246 hydrochloride

分子量	968.98
公式	C₄₉H₅₇N₁₁O₆.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	246146-31-6
InChI Key	UESZCTPNTRZXHQ-SICTUBFJSA-N
Smiles	O=C(C1=C2C=CC=C1)NC3=CC=CC=C3C2N(CC4)CCN4C(CC5(CCCC5)CC(N[C@@H](CCCNC(N)=N)C(NCCN6C(N(C7=CC=CC=C7)N(C8=CC=CC=C8)C6=O)=O)=O)=O)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIIE 0246 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	96.9	100

制备储备液 for BIIE 0246 hydrochloride

以下数据基于产品分子量 968.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.03 mL	5.16 mL	10.32 mL
5 mM	0.21 mL	1.03 mL	2.06 mL
10 mM	0.1 mL	0.52 mL	1.03 mL
50 mM	0.02 mL	0.1 mL	0.21 mL

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产品说明书 for BIIE 0246 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BIIE 0246 hydrochloride

参考文献是支持产品生物活性的出版物。

Doods et al (1999) BIIE0246: a selective and high affinity neuropeptide Y Y₂ receptor antagonist. Eur.J.Pharmacol. 384 R3 PMID: 10611450

Dumont et al (2000) BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y₂ receptor antagonist. Br.J.Pharmacol. 129 1075 PMID: 10725255

Malmstrom et al (2001) Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y₂ receptor antagonist, in vivo. Br.J.Pharmacol. 133 1073 PMID: 11487518

If you know of a relevant reference for BIIE 0246 hydrochloride, please let us know.

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关键词: BIIE 0246 hydrochloride, BIIE 0246 hydrochloride supplier, BIIE0246, dihydrochloride, 2HCl, Potent, selective, non-peptide, NPY, Y2, antagonists, Neuropeptide, Y, Receptors, neuropeptides, BIIE, 0246, 7377, Tocris Bioscience

2 篇 BIIE 0246 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIIE 0246 hydrochloride 的部分引用包括：

Sanchez et al (2021) Photo-induced receptor confinement drives ligand-independent GPCR signaling. Science 371 PMID: 33632896

Yue et al (2022) mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight 7 PMID: 36194480

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