BIO 5192

Name: BIO 5192
Brand: Tocris Bioscience
SKU: 5051
Rating: 5 (1 reviews)

Cat. No. 5051 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Highly potent and selective inhibitor of integrin α₄β₁ (VLA-4)

化学名： (2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BIO 5192

BIO 5192 is a highly selective and potent inhibitor of integrin α₄β₁ (Very Late Antigen-4; VLA-4) (K_d < 10 pM). Selectively binds α₄β₁ over a range of other integrins (IC₅₀ values are 1.8, 138, 1053, > 500 and > 10,000 nM for α₄β₁, α₉β₁, α₂β₁, α₄β₇ and α_IIbβ₃, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.

化合物库 for BIO 5192

BIO 5192 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BIO 5192

分子量	817.78
公式	C₃₈H₄₆Cl₂N₆O₈S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	327613-57-0
PubChem ID	10350459
InChI Key	MNQBPRHHZPXCKZ-ZDCRTTOTSA-N
Smiles	O=C(NC2=CC=C(CC(N(C)[C@@H](CC(C)C)C(NCC[C@@H]([C@@](O)=O)N[C@]([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)CCC3)=O)=O)=O)C=C2)NC1=CC=CC=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BIO 5192

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	81.78	100

制备储备液 for BIO 5192

以下数据基于产品分子量 817.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.22 mL	6.11 mL	12.23 mL
5 mM	0.24 mL	1.22 mL	2.45 mL
10 mM	0.12 mL	0.61 mL	1.22 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for BIO 5192

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BIO 5192

参考文献是支持产品生物活性的出版物。

Leone et al (2003) An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental aut J.Pharmacol.Exp.Ther. 305 1150 PMID: 12626659

Xu et al (2008) A chemical approach to stem-cell biology and regenerative medicine. Nature 453 338 PMID: 18480815

Ramirez et al (2009) BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 1340 1340 PMID: 19571319

Bao et al (2008) An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury. Exp.Neurol 214 160 PMID: 18926823

If you know of a relevant reference for BIO 5192, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Integrin Inhibitors

关键词: BIO 5192, BIO 5192 supplier, BIO5192, Inflammatory, mobilization, hematopoietic, stem, progenitors, AMD3100, plerixafor, HSPCs, highly, selective, potent, inhibitor, of, integrin, ⓮⓵, VLA-4, Very, Late, Antigen, 4, mobilisation, haematopoietic, inhibitors, inhibits, ste, Integrins, Stem, Cell, Signaling, Adhesion, Molecules, Hematopoietic, Cells, 5051, Tocris Bioscience

3 篇 BIO 5192 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BIO 5192 的部分引用包括：

Jeff et al (2022) Differential CXCR4 expression on hematopoietic progenitor cells versus stem cells directs homing and engraftment. JCI Insight 7 PMID: 35531956

Narendiran et al (2020) HIFα independent mechanisms in renal carcinoma cells modulate divergent outcomes in fibronectin assembly mediated by hypoxia and CoCl2. Sci Rep 10 18560 PMID: 33122751

Takizawa (2017) Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture. Exp Cell Res 358 441 PMID: 28712928

您是否知道使用了 Tocris BIO 5192 的优秀论文？请告知我们.

BIO 5192 的评论

平均评分: 5 (Based on 1 Review.)

5 星

100%

4 星

3 星

2 星

1 星

Have you used BIO 5192?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

a4b1 conformation stabilizer.

By Martin Bush on 05/10/2018

分析类型： In Vitro

种属： Human

We used this small molecule to lock a4b1 in an open conformation for EM imaging. It worked very nicely.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.