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Submit ReviewBMS 191011
说明： Potent KCa1.1 (BK) channel opener
化学名： 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
纯度： ≥98% (HPLC)
生物活性 for BMS 191011
BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).
化合物库 for BMS 191011
BMS 191011 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BMS 191011
| 分子量 | 370.71 |
| 公式 | C16H10ClF3N2O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 202821-81-6 |
| PubChem ID | 10474339 |
| InChI Key | QKOWACXSXTXRKA-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BMS 191011
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 37.07 | 100 |
制备储备液 for BMS 191011
以下数据基于产品分子量 370.71。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.7 mL | 13.49 mL | 26.98 mL |
| 5 mM | 0.54 mL | 2.7 mL | 5.4 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.7 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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产品说明书 for BMS 191011
参考文献 for BMS 191011
参考文献是支持产品生物活性的出版物。
Romine et al (2007) 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 50 528 PMID: 17266205
Hewawasam et al (2003) Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts. 13 1695
If you know of a relevant reference for BMS 191011, please let us know.
关键词: BMS 191011, BMS 191011 supplier, Potent, Maxi-K, channel, openers, BKCa, KCa11, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, BMS191011, activators, Ca2+-Activated, 2665, Tocris Bioscience
3 篇 BMS 191011 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BMS 191011 的部分引用包括：
Shukla et al (2014) Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. Am J Physiol Heart Circ Physiol 307 H134 PMID: 24816259
Eroglu et al (2012) Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors. Int J Neuropsychopharmacol 287 15886 PMID: 22418437
Martin et al (2014) Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol 7 101 PMID: 23653115
您是否知道使用了 Tocris BMS 191011 的优秀论文？ 请告知我们.
BMS 191011 的评论
平均评分: 5 (Based on 1 Review.)
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BK channel activator with great research potential.
By
Anonymous on 10/29/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK 293
The product was used to study BK channels expressed in brain. It shows moderate channel opening, works well in expperimental conditions and is stable.
Dissolve in DMSO
