BMS 193885

Cat. No. 3242 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, competitive NPY Y₁ receptor antagonist

化学名： 1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BMS 193885

BMS 193885 is a potent, competitive neuropeptide (NPY) Y₁ antagonist (K_i = 3.3 nM, IC₅₀ = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ₁, α₁, Y₂, Y₄ and Y₅ receptors respectively. Reduces food intake and body weight via central Y₁ inhibition and is brain penetrant.

技术数据 for BMS 193885

分子量	680.79
公式	C₃₃H₄₂N₄O₆.C₃H₆O₃
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	679839-66-8
PubChem ID	56972234
InChI Key	BYHJIPSVXAFCDI-WNQIDUERSA-N
Smiles	CC1=C(C(OC)=O)C(C2=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=CC=C2)C(C(OC)=O)=C(C)N1.C[C@H](O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 193885

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	13.62	20
	DMSO	68.08	100

制备储备液 for BMS 193885

以下数据基于产品分子量 680.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.47 mL	7.34 mL	14.69 mL
5 mM	0.29 mL	1.47 mL	2.94 mL
10 mM	0.15 mL	0.73 mL	1.47 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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产品说明书 for BMS 193885

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BMS 193885

参考文献是支持产品生物活性的出版物。

Poindexter et al (2004) Dihydropyridine neuropeptide Y Y₁ receptor antagonists 2: bioisosteric urea replacements Bioorg.Med.Chem. 12 507 PMID: 14723969

Antal-Zimanyi et al (2008) Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist Eur.J.Pharmacol. 590 224 PMID: 18573246

Poindexter et al (2002) Dihydropyridine neuropeptide Y Y₁ receptor antagonists. Bioorg.Med.Chem.Letts. 12 379

If you know of a relevant reference for BMS 193885, please let us know.

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关键词: BMS 193885, BMS 193885 supplier, Potent, competitive, NPY, Y1, antagonists, Peptide, Receptors, Neuropeptide, Y, BMS193885, neuropeptides, 3242, Tocris Bioscience

1 篇 BMS 193885 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 193885 的部分引用包括：

Acton et al (2019) Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep 28 625 PMID: 31315043

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.