Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBMS 986187
说明： Potent positive allosteric modulator of δ receptors
化学名： 3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
纯度： ≥98% (HPLC)
生物活性 for BMS 986187
BMS 986187 is a potent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.
化合物库 for BMS 986187
BMS 986187 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for BMS 986187
| 分子量 | 470.61 |
| 公式 | C31H34O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 684238-37-7 |
| PubChem ID | 17379334 |
| InChI Key | UEKIYVKPQNKSDI-UHFFFAOYSA-N |
| Smiles | CC(C=CC=C1)=C1COC2=CC=C(C=C2)C3C4=C(CC(C)(C)CC4=O)OC5=C3C(CC(C)(C)C5)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BMS 986187
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.41 | 20 |
制备储备液 for BMS 986187
以下数据基于产品分子量 470.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.62 mL | 53.12 mL | 106.25 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 2 mM | 1.06 mL | 5.31 mL | 10.62 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for BMS 986187
参考文献 for BMS 986187
参考文献是支持产品生物活性的出版物。
Burford et al (2015) Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 58 4220 PMID: 25901762
Shang et al (2016) Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 11 1220 PMID: 26841170
If you know of a relevant reference for BMS 986187, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: BMS 986187, BMS 986187 supplier, BMS986187, potent, delta-opioid, receptors, d-opioid, δ-opioid, positive, allosteric, modulators, PAMs, Delta, Opioid, Receptors, 5983, Tocris Bioscience
篇 BMS 986187 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 BMS 986187 的引用文献。 您是否知道使用了 Tocris BMS 986187 的优秀论文？ 请告知我们.
BMS 986187 的评论
目前没有该产品的评论。 Be the first to review BMS 986187 and earn rewards!
Have you used BMS 986187?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.