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BMS CCR2 22

Cat. No. 3129 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity, potent CCR2 antagonist
化学名： 2-[(Isopropylaminocarbonyl)amino]-N-[2-[[cis-2-[[4-(methylthio)benzoyl]amino]cyclohexyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS CCR2 22

BMS CCR2 22 is a high affinity CCR2 chemokine receptor antagonist (IC50 = 5.1 nM). Displays potent functional antagonism, IC50 values are 1 and 18 nM for chemotaxis and antagonism of calcium flux respectively. Selective over CCR3.

化合物库 for BMS CCR2 22

BMS CCR2 22 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BMS CCR2 22

分子量 593.66
公式 C28H34F3N5O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 445479-97-0
PubChem ID 24801690
InChI Key IBPXYDUJQWENPM-XZOQPEGZSA-N
Smiles O=C(N[C@@H]2CCCC[C@@H]2NC(CNC(C3=C(NC(NC(C)C)=O)C=CC(C(F)(F)F)=C3)=O)=O)C1=CC=C(SC)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS CCR2 22

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 59.37 100
ethanol 5.94 10

制备储备液 for BMS CCR2 22

以下数据基于产品分子量 593.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.42 mL 16.84 mL
5 mM 0.34 mL 1.68 mL 3.37 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for BMS CCR2 22

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BMS CCR2 22

参考文献是支持产品生物活性的出版物。

Cherney et al (2008) Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J.Med.Chem. 51 721 PMID: 18232650

You et al (2010) CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels. Mol.Pharmacol. 77 211 PMID: 19864434

If you know of a relevant reference for BMS CCR2 22, please let us know.

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关键词: BMS CCR2 22, BMS CCR2 22 supplier, High, affinity, potent, CCR2, antagonists, Chemokine, Receptors, BMSCCR222, CC, 3129, Tocris Bioscience

4 篇 BMS CCR2 22 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS CCR2 22 的部分引用包括：

Volpe et al (2012) CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One 7 e37208 PMID: 22615942

Barzilai et al (2016) M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration. J Leukoc Biol 99 1045 PMID: 26701136

Wang et al (2022) Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer. Cell Death Dis 13 748 PMID: 36038549

Wang et al (2018) Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction. Int J Nanomedicine 13 6441 PMID: 30410330

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