BOP

Cat. No. 6047 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

化学名： N-(Benzenesulfonyl)-L-prolyl-L-O-(1-pyrrolidinylcarbonyl)tyrosine sodium salt

纯度： ≥98% (HPLC)

引用文献 (4)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BOP

BOP is a dual α9β1/α4β1 integrin inhibitor; rapidly and preferentially mobilizes HSCs and progenitors. Augments HSC mobilization in combination with AMD3100 (Cat. No. 3299).

Fluorogenic, bright and photostable Fluorescent Conjugate BOP-JF646 (Cat. No. 6997) also available.

High affinity fluorescent derivative R-BC154 (Cat. No. 6048) also available.

化合物库 for BOP

BOP is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BOP

分子量	537.56
公式	C₂₅H₂₈N₃O₇SNa
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1947348-42-6
PubChem ID	10301396
InChI Key	PNMINTLPFWMZKM-VROPFNGYSA-M
Smiles	O=C([C@@H](NC([C@@H]1CCCN1S(=O)(C2=CC=CC=C2)=O)=O)CC3=CC=C(C=C3)OC(N4CCCC4)=O)O[Na]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BOP

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	53.76	100
	DMSO	53.76	100

制备储备液 for BOP

以下数据基于产品分子量 537.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.3 mL	18.6 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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产品说明书 for BOP

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BOP

参考文献是支持产品生物活性的出版物。

Cao et al (2014) Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org.Biomol.Chem. 12 965 PMID: 24363056

Pepinsky et al (2002) Comparative assessment of the ligand and metal ion binding properties of integrins α9β1 and α4β1. Biochemistry 41 7125 PMID: 12033947

Cao et al (2016) Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist. Nat.Commun. 7 11007 PMID: 26975966

If you know of a relevant reference for BOP, please let us know.

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关键词: BOP, BOP supplier, Dual, α9β/1α4β1, integrin, inhibitors, inhibits, rapidly, mobilizes, HSC, progenitors, hematopoietic, haematopoietic, stem, cells, Integrins, Cell, Adhesion, Molecules, Stem, Signaling, Hematopoietic, Cells, 6047, Tocris Bioscience

4 篇 BOP 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BOP 的部分引用包括：

Uwe et al (2020) Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma. Cancer Immunol Res 8 1122-1138 PMID: 32665262

Upadhaya et al (2020) Intravital imaging reveals motility of adult hematopoietic stem cells in the bone marrow niche Cell Stem Cell 27 336 PMID: 32589864

Jingping et al (2021) Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression. EMBO Mol Med 13 e13270 PMID: 33988305

David R et al (2021) Plasma cell dynamics in the bone marrow niche. Cell Rep 34 108733 PMID: 33567286

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.

BOP