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BRL 50481

Cat. No. 2237 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective PDE7 inhibitor
化学名： N,N,2-Trimethyl-5-nitro-benzenesulfonamide
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BRL 50481

BRL 50481 is a selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (Ki = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.

许可信息

Sold with the permission of GlaxoSmithKline

化合物库 for BRL 50481

BRL 50481 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BRL 50481

分子量 244.26
公式 C9H12N2O4S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 433695-36-4
PubChem ID 2921148
InChI Key IFIUFCJFLGCQPH-UHFFFAOYSA-N
Smiles CN(C)S(=O)(=O)C1=C(C)C=CC(=C1)[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BRL 50481

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 24.43 100
DMSO 24.43 100

制备储备液 for BRL 50481

以下数据基于产品分子量 244.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.09 mL 20.47 mL 40.94 mL
5 mM 0.82 mL 4.09 mL 8.19 mL
10 mM 0.41 mL 2.05 mL 4.09 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

Molarity Calculator

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Dilution Calculator

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参考文献 for BRL 50481

参考文献是支持产品生物活性的出版物。

Smith et al (2004) Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol.Pharmacol. 66 1679 PMID: 15371556

If you know of a relevant reference for BRL 50481, please let us know.

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关键词: BRL 50481, BRL 50481 supplier, Selective, PDE7, inhibitors, inhibits, Phosphodiesterases, BRL50481, GlaxoSmithKline, GSK, 2237, Tocris Bioscience

3 篇 BRL 50481 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BRL 50481 的部分引用包括：

Meyers et al (2009) Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors. J Immunol 182 5400 PMID: 19380787

Zhai et al (2012) β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7 e47826 PMID: 23094097

Morales-Garcia et al (2011) Phosphodiesterase 7 inhibition preserves DArgic neurons in cellular and rodent models of Parkinson disease. J Biol Chem 6 e17240 PMID: 21390306

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