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Submit ReviewBRL 52537 hydrochloride
说明： Potent and selective κ agonist
化学名： (±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for BRL 52537 hydrochloride
The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).
许可信息
Sold with the permission of GlaxoSmithKline
技术数据 for BRL 52537 hydrochloride
| 分子量 | 391.77 |
| 公式 | C18H24Cl2N2O.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 112282-24-3 |
| PubChem ID | 11315337 |
| InChI Key | NGVLSOWJSUUYDE-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=CC=C(CC(=O)N2CCCCC2CN2CCCC2)C=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BRL 52537 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.96 | 5 温和加热 |
制备储备液 for BRL 52537 hydrochloride
以下数据基于产品分子量 391.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 51.05 mL | 255.25 mL | 510.5 mL |
| 0.25 mM | 10.21 mL | 51.05 mL | 102.1 mL |
| 0.5 mM | 5.11 mL | 25.53 mL | 51.05 mL |
| 2.5 mM | 1.02 mL | 5.11 mL | 10.21 mL |
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产品说明书 for BRL 52537 hydrochloride
参考文献 for BRL 52537 hydrochloride
参考文献是支持产品生物活性的出版物。
Vecchietti et al (1991) (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 34 397 PMID: 1846921
If you know of a relevant reference for BRL 52537 hydrochloride, please let us know.
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关键词: BRL 52537 hydrochloride, BRL 52537 hydrochloride supplier, Potent, selective, κ-opioid, kappa-opioid, agonist, agonists, KOP, Receptors, OP2, BRL52537, hydrochloride, GlaxoSmithKline, GSK, Kappa, Opioid, 0699, Tocris Bioscience
1 篇 BRL 52537 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BRL 52537 hydrochloride 的部分引用包括：
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
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