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BTT 3033

Cat. No. 4724 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective inhibitor of integrin α2β1
化学名： 1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BTT 3033

BTT 3033 is a selective inhibitor of integrin α2β1 (EC50 = 130 nM for α2β1 binding to collagen I). Binds to the α2I domain. Exhibits selectivity for α2β1 over integrins α3β1, α4β1, α5β1 and αv. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α2-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A2-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.

化合物库 for BTT 3033

BTT 3033 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for BTT 3033

分子量 465.5
公式 C23H20FN5O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1259028-99-3
PubChem ID 49841251
InChI Key NSLIQOPYDUKWTA-UHFFFAOYSA-N
Smiles FC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BTT 3033

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.55 100

制备储备液 for BTT 3033

以下数据基于产品分子量 465.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

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参考文献 for BTT 3033

参考文献是支持产品生物活性的出版物。

Nissinen et al (2012) Novel a2 beta 1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 287 44694 PMID: 23132859

Li et al (2021) Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells. Ann.Transl.Med. 9 1380 PMID: 34733932

If you know of a relevant reference for BTT 3033, please let us know.

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关键词: BTT 3033, BTT 3033 supplier, BTT3033, selective, inhibitors, inhibits, integrins, receptors, alpha2beta1, α2β1, a2b1, collagen, 1, cell, adhesion, Integrins, Cell, Adhesion, Molecules, 4724, Tocris Bioscience

4 篇 BTT 3033 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BTT 3033 的部分引用包括：

Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep 8 696 PMID: 29330408

Elaine T et al (2021) Collagen I Fibrous Substrates Modulate the Proliferation and Secretome of Estrogen Receptor-Positive Breast Tumor Cells in a Hormone-Restricted Microenvironment. ACS Biomater Sci Eng 7 2430-2443 PMID: 33688723

Gertraud et al (2023) How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growth. Sci Adv 9 eadd9275 PMID: 36989370

Li et al (2021) Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells. Ann.Transl.Med. 9 1380 PMID: 34733932

您是否知道使用了 Tocris BTT 3033 的优秀论文？ 请告知我们.

BTT 3033 的评论

平均评分: 3 (Based on 1 Review.)

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Collagen type 1 activated collagen receptor discoidin domain receptor.
By Anonymous on 02/21/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： 3D Culture Matrix

10 μg/ml treat 24h and 48h

PMID: 29330408
review image

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