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Submit ReviewBudesonide
说明： Synthetic glucocorticoid; anti-inflammatory and chemopreventive
化学名： (11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
纯度： ≥98% (HPLC)
生物活性 for Budesonide
Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.
化合物库 for Budesonide
Budesonide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Budesonide
| 分子量 | 430.53 |
| 公式 | C25H34O6 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 51333-22-3 |
| PubChem ID | 5281004 |
| InChI Key | VOVIALXJUBGFJZ-KWVAZRHASA-N |
| Smiles | O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H]5[C@](C(CO)=O)4OC(CCC)O5)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Budesonide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.05 | 100 | |
| ethanol | 21.52 | 50 |
制备储备液 for Budesonide
以下数据基于产品分子量 430.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.61 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for Budesonide
参考文献 for Budesonide
参考文献是支持产品生物活性的出版物。
Spencer et al (1995) Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease. Drugs 50 854 PMID: 8586030
Pereira et al (2006) Modulation by budes. of DNA methylation and mRNA expression in mouse lung tumors. Int.J.Cancer 120 1150 PMID: 17163412
Wattenberg et al (2007) Chemoprevention of pulmonary carcinogenesis by aerosolized budes. in female A/J mice. Cancer Res. 57 5489 PMID: 9407956
If you know of a relevant reference for Budesonide, please let us know.
按标靶查看相关产品
关键词: Budesonide, Budesonide supplier, Synthetic, glucocorticoid, anti-inflammatory, chemopreventive, Receptors, Glucocorticoid, Receptor, 2671, Tocris Bioscience
3 篇 Budesonide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Budesonide 的部分引用包括：
Kim et al (2016) Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Front Endocrinol (Lausanne) NULL me20161029 PMID: 27355192
Liu et al (2015) A long-acting β2-adrenergic agonist increases the expression of muscarine cholinergic subtype-3 receptors by activating the β2-adrenoceptor cyclic adenosine monophosphate signaling pathway in airway smooth muscle cells. Mol Endocrinol 11 4121 PMID: 25672589
Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports 7 39905 PMID: 28051147
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.