Bumetanide

Cat. No. 3108 12 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Na⁺/2Cl^-/K⁺ (NKCC) symporter inhibitor

化学名： 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid

纯度： ≥98% (HPLC)

引用文献 (12)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Bumetanide

Bumetanide is a loop diuretic that inhibits the Na⁺/2Cl^-/K⁺ (NKCC) cotransporter. More potent than furosemide (Cat. No. 3109). Bumetanide improves electrophysiological, pathological and cognitive deficits in APOE4 knock-in mice. RNA sequencing of neurons derived from APOE4 induced pluripotent stem cell (iPSC) shows Bumetanide reverses Alzheimer's disease transcriptomic signatures.

化合物库 for Bumetanide

Bumetanide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Bumetanide

分子量	364.42
公式	C₁₇H₂₀N₂O₅S
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	28395-03-1
PubChem ID	2471
InChI Key	MAEIEVLCKWDQJH-UHFFFAOYSA-N
Smiles	CCCCNC1=CC(C(O)=O)=CC(S(=O)(N)=O)=C1OC2=CC=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bumetanide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	36.44	100

制备储备液 for Bumetanide

以下数据基于产品分子量 364.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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产品说明书 for Bumetanide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Bumetanide

参考文献是支持产品生物活性的出版物。

O'Grady et al (1987) Characteristics and functions of Na-K-Cl cotransport in epithelial tissues. Am.J.Physiol. 253 C177 PMID: 3303961

Isenring and Forbush (1997) Ion and bumet. binding by the Na-K-Cl cotransporter. J.Biol.Chem. 272 24556 PMID: 9305921

Morita et al (1999) Functional evidence for involvement of bumetanide-sensitive Na⁺K⁺2Cl^- cotransport in the hepatoportal Na⁺ receptor of the sprague-dawley rat. Neurosci.Letts. 264 65 PMID: 10320015

Taubes et al (2021) Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease. Nature Aging 1 932 PMID: 36172600

If you know of a relevant reference for Bumetanide, please let us know.

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