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BVT 948

Cat. No. 2176 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Non-competitive protein tyrosine phosphatase inhibitor
化学名： 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BVT 948

BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).

化合物库 for BVT 948

BVT 948 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BVT 948

分子量 241.25
公式 C14H11NO3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 39674-97-0
PubChem ID 6604934
InChI Key LLPBUXODFQZPFH-UHFFFAOYSA-N
Smiles CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BVT 948

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 12.06 50
DMSO 12.06 50

制备储备液 for BVT 948

以下数据基于产品分子量 241.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 8.29 mL 41.45 mL 82.9 mL
2.5 mM 1.66 mL 8.29 mL 16.58 mL
5 mM 0.83 mL 4.15 mL 8.29 mL
25 mM 0.17 mL 0.83 mL 1.66 mL

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产品说明书 for BVT 948

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BVT 948

参考文献是支持产品生物活性的出版物。

Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616

If you know of a relevant reference for BVT 948, please let us know.

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关键词: BVT 948, BVT 948 supplier, Non-competitive, protein, tyrosine, phosphatase, inhibitors, inhibits, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948, 2176, Tocris Bioscience

2 篇 BVT 948 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BVT 948 的部分引用包括：

Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998

Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533 PMID: 24152909

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