BX 471

Cat. No. 3496 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective CCR1 antagonist

别名： ZK-811752

化学名： (2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BX 471

BX 471 is a potent, selective non-peptide CCR1 antagonist (K_i = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca²⁺ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

化合物库 for BX 471

BX 471 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for BX 471

分子量	434.89
公式	C₂₁H₂₄ClFN₄O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	217645-70-0
PubChem ID	512282
InChI Key	XQYASZNUFDVMFH-CQSZACIVSA-N
Smiles	FC1=CC=C(CN2C[C@@H](C)N(C(COC3=CC=C(Cl)C=C3NC(N)=O)=O)CC2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BX 471

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	43.49	100
	ethanol	21.74	50

制备储备液 for BX 471

以下数据基于产品分子量 434.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.3 mL	11.5 mL	22.99 mL
5 mM	0.46 mL	2.3 mL	4.6 mL
10 mM	0.23 mL	1.15 mL	2.3 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for BX 471

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BX 471

参考文献是支持产品生物活性的出版物。

Liang (2000) Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J.Biol.Chem. 275 19000 PMID: 10748002

Anders (2002) A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J.Clin.Invest. 109 251 PMID: 11805137

Furuichi et al (2008) Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J.Immunol. 181 8670 PMID: 19050287

If you know of a relevant reference for BX 471, please let us know.

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关键词: BX 471, BX 471 supplier, selective, chemokine, receptor, antagonists, CCR1, BX471, multiple, sclerosis, renal, fibrosis, leukocyte, recruitment, Rantes, ZK-811752, Chemokine, CC, Receptors, 3496, Tocris Bioscience

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