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C 75

Cat. No. 2489 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent fatty acid synthase inhibitor; proapoptotic
别名： trans-C 75
化学名： (2R*,3S*)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C 75

C 75 is a synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.

化合物库 for C 75

C 75 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for C 75

分子量 254.32
公式 C14H22O4
储存 Store at +4°C
纯度 ≥95% (HPLC)
CAS Number 191282-48-1
PubChem ID 90488767
InChI Key VHOGWRFOUWVZQX-FBVLPHPLSA-N
Smiles C=C([C@@H]([C@](O)=O)[C@H](CCCCCCCC)O1)C1=O.C=C([C@H](C(O)=O)[C@@H](CCCCCCCC)O2)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C 75

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 25.43 100
DMSO 25.43 100

制备储备液 for C 75

以下数据基于产品分子量 254.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.32 mL
5 mM 0.79 mL 3.93 mL 7.86 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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产品说明书 for C 75

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for C 75

参考文献是支持产品生物活性的出版物。

Zhou et al (2003) Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 63 7330 PMID: 14612531

Takahashi et al (2004) The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 145 184 PMID: 14512433

Kuhajda et al (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci. 97 3450

Thupari et al (2004) Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab. 287 97

If you know of a relevant reference for C 75, please let us know.

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关键词: C 75, C 75 supplier, trans-C75, transC75, C75, fatty, acid, synthase, inhibitor, enzyme, FASanorectic, anorexigenic, neuronal, activator, inhibits, inhibitors, fat, obese, apoptosis, anti-tumor, FASN, trans-C, 75, Apoptosis, Inducers, Fatty, Acid, Synthase, 2489, Tocris Bioscience

1 篇 C 75 的引用文献

引用文献是使用了 Tocris 产品的出版物。 C 75 的部分引用包括：

Sadowski et al (2014) The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer. Oncotarget 5 9362 PMID: 25313139

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including: