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C26-A6

Cat. No. 7692 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Disrupts MTDH and SND1 interaction, enhances immune surveillance
化学名： 5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for C26-A6

C26-A2 inhibits the interaction between MTDH and SND1 by blocking the SND1 pocket. C26-A2 disrupts MTDH-SND1 complex-induced reduction in tumor antigen presentation and T cell infiltration; enhancing immune surveillance and sensitivity to anti-PD-1 therapy in metastatic breast cancer mouse models. C26-A6 suppresses tumor growth (IC50 = 12.3 μM) and metastasis and enhances chemotherapy sensitivity in triple-negative breast cancer (TNBC) mouse models.

技术数据 for C26-A6

分子量 352.79
公式 C14H13ClN4O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1341030-00-9
PubChem ID 87054166
InChI Key HLRMNXITZQAUIH-UHFFFAOYSA-N
Smiles COC1=C(S(=O)(NC2=CC=CN3N=C(N=C23)C)=O)C=C(C=C1)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for C26-A6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.28 100

制备储备液 for C26-A6

以下数据基于产品分子量 352.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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参考文献 for C26-A6

参考文献是支持产品生物活性的出版物。

Shen et al (2022) Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat.Cancer 3 43 PMID: 35121987

Shen et al (2022) Pharmacological disruption of the MTDH–SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat.Cancer 3 60 PMID: 35121988

If you know of a relevant reference for C26-A6, please let us know.

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关键词: C26-A6, C26-A6 supplier, C26A6, Inhibitors, inhibits, protein, interaction, MTDH, SND1, triple-negative, breast, cancer, TNBC, tumor, antigen, presentation, metastasis, enhances, anti-programmed, cell, death, 1, therapy, chemotherapy, sensitivity, Cell, Adhesion, Molecules, 7692, Tocris Bioscience

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