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CA 074

Cat. No. 4863 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective cathepsin B inhibitor
化学名： N-[[(2S,3S)-3-[(Propylamino)carbonyl]-2-oxiranyl]carbonyl]-L-isoleucyl-L-proline
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CA 074

CA 074 is an inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model.

技术数据 for CA 074

分子量 383.44
公式 C18H29N3O6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 134448-10-5
PubChem ID 9821383
InChI Key ZEZGJKSEBRELAS-PEDHHIEDSA-N
Smiles O=[C@](NCCC)[C@H]1O[C@@H]1[C@@](N[C@@H]([C@@H](C)CC)[C@](N2[C@H](C(O)=O)CCC2)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CA 074

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 7.67 20

制备储备液 for CA 074

以下数据基于产品分子量 383.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.04 mL 65.2 mL 130.4 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
2 mM 1.3 mL 6.52 mL 13.04 mL
10 mM 0.26 mL 1.3 mL 2.61 mL

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产品说明书 for CA 074

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CA 074

参考文献是支持产品生物活性的出版物。

Gillet et al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680 PMID: 19176528

Towatari et al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311 PMID: 2013329

Withana et al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199 PMID: 22266111

If you know of a relevant reference for CA 074, please let us know.

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关键词: CA 074, CA 074 supplier, CA074, cathepsin, B, selective, inhibitors, inhibits, cysteine, proteases, Cathepsin, Calcium-Sensitive, Proteases, 4863, Tocris Bioscience

3 篇 CA 074 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CA 074 的部分引用包括：

Hong et al (2022) LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy. EMBO Mol Med 14 e14511 PMID: 34779136

Eric et al (2019) Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Dev Cell 49 393-408.e7 PMID: 30982660

Li et al (2018) C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. Protein Cell 9 1013 PMID: 29611115

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