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Submit ReviewCabergoline
说明： D2-like agonist (D2>D3>D4)
化学名： N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
纯度： ≥99% (HPLC)
生物活性 for Cabergoline
Cabergoline is a selective D2-like dopamine receptor agonist (Ki values are 0.7, 1.5, 9.0 and 165 nM for D2, D3, D4 and D5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (Ki = 1.2 - 20.0 nM for 5-HT1A, 5-HT1D, 5-HT2A and 5-HT2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
化合物库 for Cabergoline
Cabergoline is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Cabergoline
| 分子量 | 451.6 |
| 公式 | C26H37N5O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 81409-90-7 |
| PubChem ID | 90488776 |
| InChI Key | MNDMRWBGBXWMDE-YPAWHYETSA-N |
| Smiles | C=CCN1[C@]([C@]2([H])C[C@@H](C(N(C(NCC)=O)CCCN(C)C)=O)C1)([H])CC3=CNC4=CC=CC2=C43 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cabergoline
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.16 | 100 | |
| ethanol | 45.16 | 100 |
制备储备液 for Cabergoline
以下数据基于产品分子量 451.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.21 mL | 11.07 mL | 22.14 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.21 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for Cabergoline
参考文献 for Cabergoline
参考文献是支持产品生物活性的出版物。
Eguchi et al (1995) Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J. 42 413 PMID: 7670571
Kvernmo et al (2006) A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther. 28 1065 PMID: 16982285
Hadj Tahar et al (2000) Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol. 23 195
If you know of a relevant reference for Cabergoline, please let us know.
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关键词: Cabergoline, Cabergoline supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 2664, Tocris Bioscience
4 篇 Cabergoline 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cabergoline 的部分引用包括：
Lin et al (2015) Suppression of mTOR pathway and induction of autophagy-dependent cell death by caberg. PLoS One 6 39329 PMID: 26513171
Leng et al (2017) Activation of DRD5 inhibits tumor growth by autophagic cell death. Autophagy 13 1404 PMID: 28613975
Odaka et al (2014) Cabergoline, DA D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. J Biol Chem 9 e99271 PMID: 24914776
Gao et al (2017) Expression of Stem Cell Markers and DA D2 Receptors in Human and Rat Prolactinomas. Med Sci Monit 23 1827 PMID: 28411401
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.