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Submit ReviewCaCCinh-A01
说明： Calcium-activated chloride channel (CaCC) inhibitor
化学名： 6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
纯度： ≥99% (HPLC)
生物活性 for CaCCinh-A01
CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC50 ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC50 = 2.1 μM, in TMEM16A-expressing FRT cells).
技术数据 for CaCCinh-A01
| 分子量 | 347.43 |
| 公式 | C18H21NO4S |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 407587-33-1 |
| PubChem ID | 2898877 |
| InChI Key | ACLUEOBQFRYTQS-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1CCC2=C(SC(NC(C3=CC=CO3)=O)=C2C(O)=O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CaCCinh-A01
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.74 | 100 | |
| ethanol | 3.47 | 10 温和加热 |
制备储备液 for CaCCinh-A01
以下数据基于产品分子量 347.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for CaCCinh-A01
参考文献 for CaCCinh-A01
参考文献是支持产品生物活性的出版物。
Namkung et al (2011) TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem. 286 2365 PMID: 21084298
De La Fuente et al (2008) Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol. 73 758 PMID: 18083779
If you know of a relevant reference for CaCCinh-A01, please let us know.
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关键词: CaCCinh-A01, CaCCinh-A01 supplier, calcium-activated, chloride, channels, CaCC, inhibitors, inhibits, TMEM16A, Ca2+-Activated, Chloride, Channels, 4877, Tocris Bioscience
7 篇 CaCCinh-A01 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CaCCinh-A01 的部分引用包括：
Kamran et al (2023) Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis. Nat Commun 14 616 PMID: 36739273
Dwivedi et al (2023) The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells Eur J Pharmacol PMID: 36967079
Amjad et al (2015) Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol 145 285 PMID: 25779870
Armen et al (2022) Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine. Br J Pharmacol 179 1187-1200 PMID: 34519057
Rui et al (2020) Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun 11 2165 PMID: 32358493
Richard C et al (2020) The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proc Natl Acad Sci U S A 117 28485-28495 PMID: 33097666
Zaitseva et al (2017) Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine. Cell Host Microbe 22 99 PMID: 28704658
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Pathways for CaCCinh-A01
